node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
daf-9 | dhs-17 | T13C5.1a.1 | F29G9.6b.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | DeHydrogenases, Short chain. | 0.467 |
daf-9 | eak-3 | T13C5.1a.1 | Y92C3A.3.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Enhancer of AKt-1 null. | 0.663 |
daf-9 | eak-4 | T13C5.1a.1 | F53B2.3.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | 0.692 |
daf-9 | eak-6 | T13C5.1a.1 | F10G8.4b.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Tyrosine-protein phosphatase non-receptor type eak-6; Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. | 0.581 |
daf-9 | eak-7 | T13C5.1a.1 | K08E7.1.2 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | TLDc domain-containing protein. | 0.670 |
daf-9 | hsd-1 | T13C5.1a.1 | Y6B3B.11.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 3Beta_HSD domain-containing protein. | 0.905 |
daf-9 | sdf-9 | T13C5.1a.1 | Y44A6D.4.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. | 0.758 |
dhs-17 | daf-9 | F29G9.6b.1 | T13C5.1a.1 | DeHydrogenases, Short chain. | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 0.467 |
dhs-17 | eak-4 | F29G9.6b.1 | F53B2.3.1 | DeHydrogenases, Short chain. | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | 0.697 |
dhs-17 | sdf-9 | F29G9.6b.1 | Y44A6D.4.1 | DeHydrogenases, Short chain. | Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. | 0.667 |
eak-3 | daf-9 | Y92C3A.3.1 | T13C5.1a.1 | Enhancer of AKt-1 null. | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 0.663 |
eak-3 | eak-4 | Y92C3A.3.1 | F53B2.3.1 | Enhancer of AKt-1 null. | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | 0.902 |
eak-3 | eak-6 | Y92C3A.3.1 | F10G8.4b.1 | Enhancer of AKt-1 null. | Tyrosine-protein phosphatase non-receptor type eak-6; Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. | 0.913 |
eak-3 | eak-7 | Y92C3A.3.1 | K08E7.1.2 | Enhancer of AKt-1 null. | TLDc domain-containing protein. | 0.810 |
eak-3 | hpd-1 | Y92C3A.3.1 | T21C12.2.1 | Enhancer of AKt-1 null. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.465 |
eak-3 | hsd-1 | Y92C3A.3.1 | Y6B3B.11.1 | Enhancer of AKt-1 null. | 3Beta_HSD domain-containing protein. | 0.704 |
eak-3 | sdf-9 | Y92C3A.3.1 | Y44A6D.4.1 | Enhancer of AKt-1 null. | Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. | 0.884 |
eak-4 | daf-9 | F53B2.3.1 | T13C5.1a.1 | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 0.692 |
eak-4 | dhs-17 | F53B2.3.1 | F29G9.6b.1 | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | DeHydrogenases, Short chain. | 0.697 |
eak-4 | eak-3 | F53B2.3.1 | Y92C3A.3.1 | Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1. | Enhancer of AKt-1 null. | 0.902 |