STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F53E4.1Uncharacterized protein. (432 aa)    
Predicted Functional Partners:
elb-1
RNA polymerase II transcription factor SIII p18 subunit.
    
 
 0.659
cul-2
Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...]
    
 
 0.602
F42F12.4
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
    
   0.564
mrpl-2
Ribosomal_L2_C domain-containing protein.
   
  
 0.433
F54F7.10
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
   0.432
elc-2
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
    
   0.432
elc-1
Skp1_POZ domain-containing protein.
    
   0.432
M05D6.2
Uncharacterized protein.
   
  
 0.417
cky-1
BHLH-PAS factor.
 
    
 0.407
Y50D7A.3
Protein kinase domain-containing protein.
      
 0.402
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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