STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rab-11.1Ras-related protein rab-11.1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cor [...] (211 aa)    
Predicted Functional Partners:
F54C9.11
Uncharacterized protein.
    
 0.976
rfip-1
FIP-RBD domain-containing protein.
   
 0.970
hum-2
Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 
 0.923
gdi-1
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
   
 
 0.916
pifk-1
PhosphoInositide Four Kinase (PI-4 Kinase); Belongs to the PI3/PI4-kinase family.
    
 
 0.910
rab-11.2
RAB family.
  
 
0.906
rei-2
Guanine nucleotide exchange factor rei-2; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1 (By similarity). May spatially and temporally regulate the distribution of Rab-11.1 to target membranes during embryogenesis. May play a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows ; Belongs to the SH3BP5 family.
   
 
 0.862
rab-1
RAB family.
  
0.844
exoc-7
Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
   
 0.841
exoc-8
Exo84_C domain-containing protein.
   
 0.825
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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