STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
saeg-1Suppressor of activated egl-4 protein 1; As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP- dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging. (900 aa)    
Predicted Functional Partners:
saeg-2
Suppressor of activated egl-4 protein 2; As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP- dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.
   
 
 0.948
C08F11.12
UPF0375 protein C08F11.12.
      
 0.807
hda-2
Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...]
    
 
 0.767
Y45F10C.2
UPF0375 protein Y45F10C.2; Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.
      
 0.741
ZC477.3
Uncharacterized protein.
      
 0.634
hlh-11
Helix-loop-helix protein 11.
   
  
 0.494
che-11
Uncharacterized protein.
   
  
 0.408
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
   
  
 0.404
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.