node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0024.15 | Y105E8A.1 | B0024.15.2 | Y105E8A.1b.1 | Hexosyltransferase. | Glutaredoxin domain-containing protein. | 0.806 |
B0024.15 | dnsn-1 | B0024.15.2 | C24H12.5b.1 | Hexosyltransferase. | Downstream Neighbor of SoN homolog. | 0.762 |
B0024.15 | pdxk-1 | B0024.15.2 | F57C9.1b.1 | Hexosyltransferase. | Putative pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6. | 0.741 |
B0024.15 | rcan-1 | B0024.15.2 | F54E7.7.1 | Hexosyltransferase. | Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. | 0.612 |
B0024.15 | set-29 | B0024.15.2 | Y92H12BR.6.1 | Hexosyltransferase. | SET domain-containing protein. | 0.803 |
Y105E8A.1 | B0024.15 | Y105E8A.1b.1 | B0024.15.2 | Glutaredoxin domain-containing protein. | Hexosyltransferase. | 0.806 |
Y105E8A.1 | dnsn-1 | Y105E8A.1b.1 | C24H12.5b.1 | Glutaredoxin domain-containing protein. | Downstream Neighbor of SoN homolog. | 0.803 |
Y105E8A.1 | pdxk-1 | Y105E8A.1b.1 | F57C9.1b.1 | Glutaredoxin domain-containing protein. | Putative pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6. | 0.783 |
Y105E8A.1 | rcan-1 | Y105E8A.1b.1 | F54E7.7.1 | Glutaredoxin domain-containing protein. | Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. | 0.660 |
Y105E8A.1 | set-29 | Y105E8A.1b.1 | Y92H12BR.6.1 | Glutaredoxin domain-containing protein. | SET domain-containing protein. | 0.808 |
abcx-1 | rcan-1 | C56E6.1.1 | F54E7.7.1 | ABC transporter, eXtended. | Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. | 0.665 |
cmd-1 | cnb-1 | T21H3.3a.1 | F55C10.1a.1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] | 0.963 |
cmd-1 | rcan-1 | T21H3.3a.1 | F54E7.7.1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. | 0.598 |
cmd-1 | tax-6 | T21H3.3a.1 | C02F4.2b.1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.994 |
cnb-1 | cmd-1 | F55C10.1a.1 | T21H3.3a.1 | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.963 |
cnb-1 | rcan-1 | F55C10.1a.1 | F54E7.7.1 | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] | Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. | 0.936 |
cnb-1 | tax-6 | F55C10.1a.1 | C02F4.2b.1 | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] | 0.999 |
dnsn-1 | B0024.15 | C24H12.5b.1 | B0024.15.2 | Downstream Neighbor of SoN homolog. | Hexosyltransferase. | 0.762 |
dnsn-1 | Y105E8A.1 | C24H12.5b.1 | Y105E8A.1b.1 | Downstream Neighbor of SoN homolog. | Glutaredoxin domain-containing protein. | 0.803 |
dnsn-1 | pdxk-1 | C24H12.5b.1 | F57C9.1b.1 | Downstream Neighbor of SoN homolog. | Putative pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6. | 0.855 |