STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
klf-3Kruppel-Like Factor (Zinc finger protein). (315 aa)    
Predicted Functional Partners:
ctbp-1
C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism.
   
 
 0.737
acox-1.2
Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.
      
 0.660
wwp-1
E3 ubiquitin-protein ligase.
    
 
 0.594
C16E9.1
Uncharacterized protein.
   
 
 0.559
acox-1.1
Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.
   
  
 0.553
ubc-9
SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.510
dsc-4
Microsomal triglyceride transfer protein.
   
  
 0.492
acs-1
Fatty Acid CoA Synthetase family.
   
 
 0.477
C18H7.1
VWFA domain-containing protein.
    
 
 0.474
jun-1
Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation.
   
 
 0.449
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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