STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
twk-24TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (579 aa)    
Predicted Functional Partners:
kcnl-3
Small conductance calcium-activated potassium channel-like protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium.
      
 0.702
col-156
Col_cuticle_N domain-containing protein.
      
 0.698
shw-3
BTB domain-containing protein; Belongs to the potassium channel family.
   
  
 0.693
col-107
Col_cuticle_N domain-containing protein.
   
  
 0.674
nhx-8
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      
 0.669
egas-2
EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.669
tps-2
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2; Catalyzes the production of trehalose from glucose-6- phosphate and UDP-alpha-D-glucose in a 2 step process; In the N-terminal section; belongs to the glycosyltransferase 20 family.
      
 0.615
kcnl-2
CaMBD domain-containing protein.
   
  
 0.531
vha-19
Vacuolar H ATPase.
      
 0.510
vha-7
V-type proton ATPase subunit a.
      
 0.468
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.