TPR_REGION domain-containing protein.

RIM Binding protein.

JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...]

Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...]

Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites.

Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...]

Serine/threonine-protein kinase zyg-8; Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase.

Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...]

Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...]