node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccpp-1 | klp-11 | F56H1.5.1 | F20C5.2a.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.834 |
ccpp-1 | klp-6 | F56H1.5.1 | R144.1.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.894 |
ccpp-1 | osm-3 | F56H1.5.1 | M02B7.3b.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. | 0.816 |
ccpp-1 | spas-1 | F56H1.5.1 | C24B5.2c.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | 0.838 |
ccpp-1 | ttll-11 | F56H1.5.1 | H23L24.3b.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] | 0.942 |
ccpp-1 | ttll-12 | F56H1.5.1 | D2013.9.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Tubulin--tyrosine ligase-like protein 12; Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. | 0.860 |
ccpp-1 | ttll-15 | F56H1.5.1 | K07C5.7.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Probable tubulin polyglutamylase ttll-15; Probable polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. | 0.910 |
ccpp-1 | ttll-4 | F56H1.5.1 | ZK1128.6a.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. | 0.957 |
ccpp-1 | ttll-5 | F56H1.5.1 | C55A6.2b.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons. | 0.945 |
ccpp-1 | ttll-9 | F56H1.5.1 | F25C8.5.1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth. | 0.921 |
klp-11 | ccpp-1 | F20C5.2a.1 | F56H1.5.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | 0.834 |
klp-11 | klp-6 | F20C5.2a.1 | R144.1.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.654 |
klp-11 | osm-3 | F20C5.2a.1 | M02B7.3b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. | 0.740 |
klp-11 | ttll-11 | F20C5.2a.1 | H23L24.3b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] | 0.713 |
klp-11 | ttll-4 | F20C5.2a.1 | ZK1128.6a.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. | 0.757 |
klp-11 | ttll-5 | F20C5.2a.1 | C55A6.2b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons. | 0.544 |
klp-11 | ttll-9 | F20C5.2a.1 | F25C8.5.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth. | 0.500 |
klp-6 | ccpp-1 | R144.1.1 | F56H1.5.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. | 0.894 |
klp-6 | klp-11 | R144.1.1 | F20C5.2a.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.654 |
klp-6 | osm-3 | R144.1.1 | M02B7.3b.1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. | 0.648 |