STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yif-1YIP1-Interacting Factor homolog. (380 aa)    
Predicted Functional Partners:
F32D8.14
Protein YIPF.
   
 
 0.952
rps-22
Ribosomal Protein, Small subunit; Belongs to the universal ribosomal protein uS8 family.
      
 0.761
impt-1
Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family.
   
  
 0.697
col-97
Col_cuticle_N domain-containing protein.
      
 0.692
Y25C1A.7
Yip1 domain-containing protein.
   
  
 0.677
F21D5.7
Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.
   
  
 0.674
rpl-24.1
60S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family.
      
 0.666
cerk-1
Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate.
   
  
 0.660
Y37E3.8
Ribosomal_L18e/L15P domain-containing protein; Belongs to the universal ribosomal protein uL15 family.
      
 0.660
W09G3.8
Uncharacterized protein.
    
 
 0.654
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.