NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.

Probable aldehyde oxidase gad-3; May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1. Belongs to the xanthine dehydrogenase family.

HIG1 domain-containing protein.

Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.

Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...]

Dimethylaniline monooxygenase [N-oxide-forming].

Regulator of hypoxia-inducible factor 1; Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1- independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis.

Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons.

Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.