STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F57B9.8Tyrosine-protein kinase. (444 aa)    
Predicted Functional Partners:
F23C8.8
Protein kinase domain-containing protein.
  
 
 0.660
Y116A8C.24
Tyrosine-protein kinase.
  
   
0.625
R08A2.2
Serine/threonine-protein phosphatase.
   
   0.620
F40G12.10
Uncharacterized protein.
   
   0.598
his-70
Histone H3.3-like type 1; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
   
 
 0.590
E02D9.1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
 
 0.588
acs-18
AMP-binding domain-containing protein.
   
 
 0.584
Y119C1B.1
Uncharacterized protein.
   
   0.579
T02E1.7
Uncharacterized protein T02E1.7; Belongs to the SURF4 family.
   
   0.573
acs-10
Fatty Acid CoA Synthetase family.
   
   0.562
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.