STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unc-42Homeobox domain-containing protein. (279 aa)    
Predicted Functional Partners:
unc-3
Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
   
  
 0.828
unc-86
Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...]
   
  
 0.766
fax-1
Nuclear receptor domain-containing protein.
   
  
 0.763
cfi-1
AT-rich interactive domain-containing protein cfi-1; Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.
   
 
 0.743
dpy-11
Thioredoxin domain-containing protein.
    
 
 0.721
hlh-34
Helix-loop-helix 34; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development (By similarity).
   
  
 0.693
nmr-1
NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
   
  
 0.665
pept-3
Peptide transporter 3; Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)- independent manner. Shows H(+) channel activity in the absence of peptide substrates; Belongs to the PTR2/POT transporter (TC 2.A.17) family.
   
 
 0.664
nmr-2
NMDA-type ionotropic glutamate receptor NMR-2.
      
 0.660
sta-1
Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor.
      
 0.648
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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