STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ddl-1WASH complex subunit homolog 3; Belongs to the CCDC53 family. (189 aa)    
Predicted Functional Partners:
ddl-2
WASH_WAHD domain-containing protein.
    
 0.998
hsb-1
Heat Shock factor Binding protein.
   
 0.996
hsf-1
HSF_DOMAIN domain-containing protein.
    
 0.975
T05E7.3
Uncharacterized protein.
   
 0.941
Y53F4B.21
Uncharacterized protein.
    
 0.913
ddl-3
Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased).
   
  
 0.700
sinh-1
Stress-activated map kinase-interacting protein 1 homolog; May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
   
  
 0.667
C24D10.1
Protein Tyrosine Phosphatase.
      
 0.663
ttr-1
Transthyretin-like protein 1.
      
 0.661
daf-16
Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...]
      
 0.582
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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