STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ver-3Tyrosine-protein kinase receptor ver-3; Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail. (1227 aa)    
Predicted Functional Partners:
let-756
Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.
   
 0.934
sem-5
Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...]
   
 0.932
sqst-5
Protein ver-2; May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.
      
 0.851
plc-3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...]
    
 0.726
gnrr-3
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.700
aap-1
Phosphoinositide 3-kinase adapter subunit.
    
 0.697
pvf-1
PDGF_2 domain-containing protein.
    
 0.684
baz-2
Bromodomain Adjacent to Zinc finger domain, 2A/2B, homolog.
   
 
 0.677
gnrr-2
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.664
F09A5.2
Putative tyrosine-protein kinase F09A5.2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
  
  
0.644
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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