Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| elks-1 | git-1 | F42A6.9.1 | F14F3.2.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | 0.866 |
| elks-1 | hlb-1 | F42A6.9.1 | T21H8.1h.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | 0.449 |
| elks-1 | lin-2 | F42A6.9.1 | F17E5.1a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. | 0.475 |
| elks-1 | rab-3 | F42A6.9.1 | C18A3.6a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | 0.876 |
| elks-1 | rimb-1 | F42A6.9.1 | Y39A3CL.2.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | RIM Binding protein. | 0.883 |
| elks-1 | rsy-1 | F42A6.9.1 | Y53H1A.1a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Regulator of SYnapse formation. | 0.817 |
| elks-1 | syd-1 | F42A6.9.1 | F35D2.5a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. | 0.898 |
| elks-1 | syd-2 | F42A6.9.1 | F59F5.6.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.982 |
| elks-1 | unc-10 | F42A6.9.1 | T10A3.1a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.984 |
| elks-1 | unc-13 | F42A6.9.1 | ZK524.2d.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. | 0.842 |
| git-1 | elks-1 | F14F3.2.1 | F42A6.9.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | 0.866 |
| git-1 | hlb-1 | F14F3.2.1 | T21H8.1h.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | 0.670 |
| git-1 | syd-2 | F14F3.2.1 | F59F5.6.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.987 |
| git-1 | unc-10 | F14F3.2.1 | T10A3.1a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.554 |
| hlb-1 | elks-1 | T21H8.1h.1 | F42A6.9.1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | 0.449 |
| hlb-1 | git-1 | T21H8.1h.1 | F14F3.2.1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | 0.670 |
| hlb-1 | rsy-1 | T21H8.1h.1 | Y53H1A.1a.1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | Regulator of SYnapse formation. | 0.463 |
| hlb-1 | syd-2 | T21H8.1h.1 | F59F5.6.1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.966 |
| hlb-1 | unc-10 | T21H8.1h.1 | T10A3.1a.1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.474 |
| lin-2 | elks-1 | F17E5.1a.1 | F42A6.9.1 | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | 0.475 |
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