STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H01M10.2Uncharacterized protein. (260 aa)    
Predicted Functional Partners:
F26A1.1
Uncharacterized protein.
      
 0.907
nfi-1
CTF/NF-I domain-containing protein.
      
 0.700
K09B3.1
ShKT domain-containing protein.
      
 0.697
nhr-277
Nuclear Hormone Receptor family.
      
 0.697
sdc-3
Zinc finger protein sdc-3; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reductio [...]
      
 0.660
hlh-1
Myoblast determination protein 1 homolog; Accumulation defines the body wall muscle cell fate during embryogenesis. Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2.
      
 0.621
F01G4.4
Uncharacterized protein.
      
 0.612
sdc-2
Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...]
      
 0.532
mix-1
Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...]
      
 0.468
flp-4
FMRFamide-like peptide 4.
      
 0.463
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.