STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nsf-1Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family. (824 aa)    
Predicted Functional Partners:
snap-1
SNAP (Soluble NSF Attachment Protein) homolog.
   
 0.953
sec-22
Yeast SEC homolog; Belongs to the synaptobrevin family.
    
 0.828
sly-1
SLY1 homolog; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.818
unc-64
Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...]
   
 
 0.804
syx-5
Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.
    
 0.798
ykt-6
YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family.
   
 0.794
syx-17
t-SNARE coiled-coil homology domain-containing protein.
   
 0.792
snb-1
Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function.
   
 0.776
syx-18
t-SNARE coiled-coil homology domain-containing protein.
   
 0.761
nbet-1
t-SNARE coiled-coil homology domain-containing protein.
    
 0.759
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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