asp-3 protein (Caenorhabditis elegans) - STRING interaction network

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Predicted Interactions

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Score

asp-3

Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)

Predicted Functional Partners:

F57F5.1

0.980

asp-5

0.973

cpr-1

0.970

cpr-4

0.963

cpr-5

0.962

cpr-6

0.949

F32H5.1

0.940

cpr-3

0.933

cpr-8

0.933

W07B8.4

0.930

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F32H5.1	asp-3	F32H5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.940
F32H5.1	asp-5	F32H5.1.1	F21F8.3.2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.530
F57F5.1	asp-3	F57F5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.980
F57F5.1	asp-5	F57F5.1.1	F21F8.3.2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.749
F57F5.1	cpr-1	F57F5.1.1	C52E4.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.670
F57F5.1	cpr-5	F57F5.1.1	W07B8.5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.613
W07B8.4	asp-3	W07B8.4a.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.930
W07B8.4	asp-5	W07B8.4a.1	F21F8.3.2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.451
asp-3	F32H5.1	H22K11.1.1	F32H5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.940
asp-3	F57F5.1	H22K11.1.1	F57F5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.980
asp-3	W07B8.4	H22K11.1.1	W07B8.4a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.930
asp-3	asp-5	H22K11.1.1	F21F8.3.2	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.973
asp-3	cpr-1	H22K11.1.1	C52E4.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.970
asp-3	cpr-3	H22K11.1.1	T10H4.12.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family.	0.933
asp-3	cpr-4	H22K11.1.1	F44C4.3.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family.	0.963
asp-3	cpr-5	H22K11.1.1	W07B8.5.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.962
asp-3	cpr-6	H22K11.1.1	C25B8.3a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family.	0.949
asp-3	cpr-8	H22K11.1.1	W07B8.1a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.933
asp-5	F32H5.1	F21F8.3.2	F32H5.1.1	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.530
asp-5	F57F5.1	F21F8.3.2	F57F5.1.1	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.749

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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