STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkb-1.26-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; Synthesis and degradation of fructose 2,6-bisphosphate. (457 aa)    
Predicted Functional Partners:
pfk-1.2
ATP-dependent 6-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.819
rad-50
DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.
  
  
 0.816
pfkb-1.1
6PF2K domain-containing protein.
  
  
0.809
pgk-1
Probable phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
 
 0.760
gpd-3
Glyceraldehyde-3-phosphate dehydrogenase 3.
   
 0.749
fbp-1
FBPase domain-containing protein; Belongs to the FBPase class 1 family.
   
 
 0.719
gpd-4
Glyceraldehyde-3-phosphate dehydrogenase 4.
 
 
 0.692
pfk-1.1
ATP-dependent 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.692
F20D6.11
Rieske domain-containing protein.
    
 
 0.674
gpd-1
Glyceraldehyde-3-phosphate dehydrogenase 1.
 
 
 0.671
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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