node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | ced-3 | T25C8.2.2 | C48D1.2a.1 | ACTin. | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] | 0.726 |
act-5 | gsnl-1 | T25C8.2.2 | K06A4.3.1 | ACTin. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.997 |
act-5 | pfn-1 | T25C8.2.2 | Y18D10A.20.1 | ACTin. | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. | 0.999 |
act-5 | pfn-2 | T25C8.2.2 | F35C8.6.1 | ACTin. | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). | 0.999 |
act-5 | pfn-3 | T25C8.2.2 | K03E6.6.1 | ACTin. | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. | 0.999 |
act-5 | unc-60 | T25C8.2.2 | C38C3.5.1 | ACTin. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.999 |
act-5 | viln-1 | T25C8.2.2 | C10H11.1.1 | ACTin. | HP domain-containing protein. | 0.710 |
ced-3 | act-5 | C48D1.2a.1 | T25C8.2.2 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] | ACTin. | 0.726 |
ced-3 | gsnl-1 | C48D1.2a.1 | K06A4.3.1 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.859 |
cogc-3 | cogc-6 | Y71F9AM.4a.1 | K07C11.9.1 | Conserved Oligomeric Golgi (COG) Component. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.995 |
cogc-3 | cogc-8 | Y71F9AM.4a.1 | R02D3.2.1 | Conserved Oligomeric Golgi (COG) Component. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.993 |
cogc-3 | gsnl-1 | Y71F9AM.4a.1 | K06A4.3.1 | Conserved Oligomeric Golgi (COG) Component. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.862 |
cogc-6 | cogc-3 | K07C11.9.1 | Y71F9AM.4a.1 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved Oligomeric Golgi (COG) Component. | 0.995 |
cogc-6 | cogc-8 | K07C11.9.1 | R02D3.2.1 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.995 |
cogc-6 | gsnl-1 | K07C11.9.1 | K06A4.3.1 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.876 |
cogc-8 | cogc-3 | R02D3.2.1 | Y71F9AM.4a.1 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved Oligomeric Golgi (COG) Component. | 0.993 |
cogc-8 | cogc-6 | R02D3.2.1 | K07C11.9.1 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.995 |
cogc-8 | gsnl-1 | R02D3.2.1 | K06A4.3.1 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.912 |
gsnl-1 | act-5 | K06A4.3.1 | T25C8.2.2 | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | ACTin. | 0.997 |
gsnl-1 | ced-3 | K06A4.3.1 | C48D1.2a.1 | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] | 0.859 |