K07A1.6 protein (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

K07A1.6

TIL domain-containing protein. (100 aa)

Predicted Functional Partners:

D1054.10

0.999

F17E9.4

0.999

Y62H9A.3

0.999

Y62H9A.4

0.999

ZK813.7

0.922

W02D9.7

0.884

ZK813.1

0.874

Y62H9A.5

0.847

F55B11.2

0.846

F57C2.4

0.846

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D1054.10	F17E9.4	D1054.10.1	F17E9.4.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	F55B11.2	D1054.10.1	F55B11.2.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	F57C2.4	D1054.10.1	F57C2.4.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	K07A1.6	D1054.10.1	K07A1.6.1	Uncharacterized protein.	TIL domain-containing protein.	0.999
D1054.10	W02D9.7	D1054.10.1	W02D9.7.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	Y62H9A.3	D1054.10.1	Y62H9A.3.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	Y62H9A.4	D1054.10.1	Y62H9A.4.2	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	Y62H9A.5	D1054.10.1	Y62H9A.5.1	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	ZK813.1	D1054.10.1	ZK813.1.2	Uncharacterized protein.	Uncharacterized protein.	0.999
D1054.10	ZK813.7	D1054.10.1	ZK813.7.1	Uncharacterized protein.	Uncharacterized protein.	0.629
F17E9.4	D1054.10	F17E9.4.1	D1054.10.1	Uncharacterized protein.	Uncharacterized protein.	0.999
F17E9.4	F55B11.2	F17E9.4.1	F55B11.2.1	Uncharacterized protein.	Uncharacterized protein.	0.982
F17E9.4	F57C2.4	F17E9.4.1	F57C2.4.1	Uncharacterized protein.	Uncharacterized protein.	0.916
F17E9.4	K07A1.6	F17E9.4.1	K07A1.6.1	Uncharacterized protein.	TIL domain-containing protein.	0.999
F17E9.4	W02D9.7	F17E9.4.1	W02D9.7.1	Uncharacterized protein.	Uncharacterized protein.	0.846
F17E9.4	Y62H9A.3	F17E9.4.1	Y62H9A.3.1	Uncharacterized protein.	Uncharacterized protein.	0.999
F17E9.4	Y62H9A.4	F17E9.4.1	Y62H9A.4.2	Uncharacterized protein.	Uncharacterized protein.	0.999
F17E9.4	Y62H9A.5	F17E9.4.1	Y62H9A.5.1	Uncharacterized protein.	Uncharacterized protein.	0.874
F17E9.4	ZK813.1	F17E9.4.1	ZK813.1.2	Uncharacterized protein.	Uncharacterized protein.	0.846
F17E9.4	ZK813.7	F17E9.4.1	ZK813.7.1	Uncharacterized protein.	Uncharacterized protein.	0.846

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

15

PPI enrichment p-value:

2.84e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046463

Acylglycerol biosynthetic process

8 of 25

2.82

8.73

1.07e-17

GO:0006639

Acylglycerol metabolic process

9 of 69

2.43

7.84

1.07e-17

GO:0006641

Triglyceride metabolic process

8 of 46

2.55

7.7

1.60e-16

GO:0019432

Triglyceride biosynthetic process

5 of 14

2.87

5.42

7.19e-11

GO:0016042

Lipid catabolic process

8 of 257

1.81

3.77

4.52e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008195

Phosphatidate phosphatase activity

5 of 21

2.69

4.64

1.59e-09

GO:0016411

Acylglycerol O-acyltransferase activity

4 of 22

2.57

3.39

3.88e-07

GO:0016788

Hydrolase activity, acting on ester bonds

9 of 845

1.34

2.03

9.96e-09

GO:0003713

Transcription coactivator activity

4 of 173

1.68

1.54

0.00038

GO:0016298

Lipase activity

3 of 117

1.72

1.13

0.0049

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005811

Lipid droplet

3 of 64

1.98

1.2

0.0049

GO:0005783

Endoplasmic reticulum

6 of 1378

0.95

0.63

0.0112

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27384

Glycerolipid metabolism, and Glycerophospholipid metabolism

11 of 152

2.17

7.76

8.77e-21

CL:27488

Triglyceride biosynthesis, and Diacylglycerol diphosphate phosphatase activity

6 of 19

2.81

6.4

6.62e-13

CL:27490

Triglyceride biosynthesis, and sphingosine-1-phosphate phosphatase activity

5 of 12

2.93

5.6

3.74e-11

CL:27636

Acyl chain remodeling of DAG and TAG

4 of 5

3.22

4.78

1.92e-09

CL:27385

Glycerolipid metabolism, and Glycerophospholipid metabolism

7 of 114

2.1

4.63

2.58e-11

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00561

Glycerolipid metabolism

10 of 129

2.2

7.6

1.18e-19

map00564

Glycerophospholipid metabolism

5 of 196

1.72

2.33

2.28e-06

map04150

mTOR signaling pathway

4 of 224

1.56

1.59

0.00015

map01100

Metabolic pathways

9 of 3105

0.77

0.71

4.85e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75109

Triglyceride biosynthesis

6 of 18

2.84

6.46

5.54e-13

MAP-8979227

Triglyceride metabolism

6 of 37

2.52

5.58

8.33e-12

MAP-1482883

Acyl chain remodeling of DAG and TAG

4 of 10

2.91

4.35

9.02e-09

MAP-1483206

Glycerophospholipid biosynthesis

8 of 202

1.91

4.3

6.46e-12

MAP-4419969

Depolymerisation of the Nuclear Lamina

4 of 19

2.64

3.81

6.32e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

6 of 566

1.34

1.35

0.00015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

3 of 49

2.1

1.64

0.00065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16876

Lipin/Ned1/Smp2 multi-domain protein middle domain

4 of 4

3.31

4.6

4.41e-09

PF04571

Lipin, N-terminal conserved region

4 of 5

3.22

4.59

4.41e-09

PF03982

Diacylglycerol acyltransferase

2 of 4

3.01

1.47

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00775

This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins. SMP2 is involved in plasmid maintenance and respiration. Lipin proteins are involved in adipose tissue ...

4 of 8

3.01

4.35

1.03e-08

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