node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C27D9.2 | mup-4 | C27D9.2.1 | K07D8.1.1 | Uncharacterized protein. | Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos. | 0.691 |
ifb-1 | let-805 | F10C1.2b.1 | H19M22.2b.1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. | Myotactin form B. | 0.769 |
ifb-1 | mup-4 | F10C1.2b.1 | K07D8.1.1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. | Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos. | 0.766 |
ifb-1 | vab-10 | F10C1.2b.1 | ZK1151.1l.1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. | GAR domain-containing protein. | 0.740 |
let-4 | mua-3 | C44H4.2.1 | K08E5.3a.1 | Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | 0.750 |
let-4 | mup-4 | C44H4.2.1 | K07D8.1.1 | Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. | Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos. | 0.725 |
let-4 | noah-1 | C44H4.2.1 | C34G6.6b.1 | Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. | NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). | 0.923 |
let-4 | sym-1 | C44H4.2.1 | C44H4.3.1 | Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. | SYM-1 protein. | 0.999 |
let-805 | ifb-1 | H19M22.2b.1 | F10C1.2b.1 | Myotactin form B. | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. | 0.769 |
let-805 | mua-3 | H19M22.2b.1 | K08E5.3a.1 | Myotactin form B. | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | 0.881 |
let-805 | mup-4 | H19M22.2b.1 | K07D8.1.1 | Myotactin form B. | Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos. | 0.826 |
let-805 | noah-1 | H19M22.2b.1 | C34G6.6b.1 | Myotactin form B. | NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). | 0.444 |
let-805 | pat-2 | H19M22.2b.1 | F54F2.1.1 | Myotactin form B. | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] | 0.552 |
let-805 | vab-10 | H19M22.2b.1 | ZK1151.1l.1 | Myotactin form B. | GAR domain-containing protein. | 0.884 |
mua-3 | let-4 | K08E5.3a.1 | C44H4.2.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. | 0.750 |
mua-3 | let-805 | K08E5.3a.1 | H19M22.2b.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | Myotactin form B. | 0.881 |
mua-3 | mup-4 | K08E5.3a.1 | K07D8.1.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos. | 0.692 |
mua-3 | noah-1 | K08E5.3a.1 | C34G6.6b.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). | 0.735 |
mua-3 | pat-2 | K08E5.3a.1 | F54F2.1.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] | 0.732 |
mua-3 | sym-1 | K08E5.3a.1 | C44H4.3.1 | Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton. | SYM-1 protein. | 0.747 |