STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rpi-2Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (341 aa)    
Predicted Functional Partners:
arl-3
ADP-ribosylation factor-like protein 3; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
   
 0.986
unc-119
Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.
     
 0.924
arl-13
ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. Required for normal sensory cilium function. May act by maintaining the association between IFT subcomplexes A and B; Belongs to the small GTPase superfamily. Arf family.
   
 
 0.858
nphp-1
Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium.
   
  
 0.822
nphp-4
NePHronoPhthisis (Human kidney disease) homolog.
   
  
 0.822
xbx-1
X-BoX promoter element regulated.
   
  
 0.817
cdkl-1
Cyclin-dependent kinase-like 1; Modulates cilium assembly.
   
  
 0.813
mks-1
MecKel-Gruber Syndrome (MKS) homolog.
   
  
 0.790
mksr-2
MecKel Syndrome 1 (MKS1)-Related.
   
  
 0.769
tmem-107
TMEM (Human TransMEMbrane protein) homolog.
      
 0.758
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.