STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lge-1Glycosyltransferase-like protein LARGE; Probable glycosyltransferase; Belongs to the glycosyltransferase 8 family. (631 aa)    
Predicted Functional Partners:
bgnt-1.2
B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog.
      
 0.905
bgnt-1.4
B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog.
     
  0.900
bgnt-1.5
B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog.
     
  0.900
T07A5.1
Uncharacterized protein T07A5.1.
   
  
 0.844
M70.4
Uncharacterized protein.
      
 0.812
rfp-1
E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family.
      
 0.762
sqv-2
Beta-1,3-galactosyltransferase sqv-2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
      
 0.758
umps-1
Orotidine 5'-phosphate decarboxylase; Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. In the C-terminal section; belongs to the OMP decarboxylase family.
      
 0.741
sqv-6
Xylosyltransferase sqv-6; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
      
 0.700
ttc-7
TPR_REGION domain-containing protein.
      
 0.594
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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