STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pll-1Phosphoinositide phospholipase C. (1075 aa)    
Predicted Functional Partners:
dgk-2
Diacylglycerol kinase.
      
 0.588
dgk-3
Probable diacylglycerol kinase 3; Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels. Belongs to the eukaryotic diacylglycerol kinase family.
   
  
 0.529
mpz-1
Multiple PDZ domain protein.
   
 
 0.519
insc-1
INSCuteable (Drososphila asymmetric cell division protein) homolog.
   
 0.512
ppk-1
PIPK domain-containing protein.
   
 0.512
ppk-2
PIPK domain-containing protein.
   
 0.511
sym-3
C2 NT-type domain-containing protein.
   
 0.502
C52A11.3
PDZ domain-containing protein C52A11.3.
   
 
 0.495
ipp-5
Probable type I inositol 1,4,5-trisphosphate 5-phosphatase; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.
   
  
 0.486
itr-1
Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...]
   
  
 0.479
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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