STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
K10G6.4Uncharacterized protein. (459 aa)    
Predicted Functional Partners:
ran-1
GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
   
 
 0.905
gasr-8
GAS (Human Growth Arrest-Specific) Related.
   
  
 0.901
Y55D5A.1
Uncharacterized protein.
   
  
 0.892
C35E7.11
Uncharacterized protein.
   
  
 0.891
F10G2.1
UPF0376 protein F10G2.1.
      
 0.890
ulp-1
Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.
   
 
 0.888
dyf-19
Uncharacterized protein.
   
  
 0.862
Y57G11C.32
Uncharacterized protein.
   
  
 0.857
cdc-14
Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...]
   
 
 0.843
imb-2
Importin N-terminal domain-containing protein.
   
 
 0.754
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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