STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
K12D12.5RNase H domain-containing protein. (648 aa)    
Predicted Functional Partners:
rnh-2
Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
  
 
 0.776
mtss-1
Single-stranded DNA-binding protein, mitochondrial; Has a role in germline cell development and proliferation which affects the frequency of apoptosis. Required for mitochondrial DNA replication and transcription and fertility.
   
 
 0.573
pgk-1
Probable phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
    
 0.566
ndx-9
NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily.
    
  0.556
enol-1
Enolase; Belongs to the enolase family.
  
 
  0.545
nfx-1
Transcriptional repressor NF-X1 homolog; May play a role in transcription regulation; Belongs to the NFX1 family.
   
    0.517
gpd-4
Glyceraldehyde-3-phosphate dehydrogenase 4.
  
 
 0.513
gpd-1
Glyceraldehyde-3-phosphate dehydrogenase 1.
  
 
 0.507
W03D8.7
Uncharacterized protein.
  
 
 0.477
gpd-3
Glyceraldehyde-3-phosphate dehydrogenase 3.
  
 
 0.464
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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