STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ipla-1DDHD domain-containing protein. (840 aa)    
Predicted Functional Partners:
tbc-3
Rab-GAP TBC domain-containing protein.
   
  
 0.859
mon-2
Monensin-resistant homolog 2; May be required for traffic between late Golgi and early endosomes.
   
  
 0.837
acl-8
PlsC domain-containing protein.
   
  
 0.817
ipla-2
Intracelllar PhosphoLipase A family.
   
  
 0.785
Y69A2AL.2
Phospholipase A(2).
      
 0.758
ipla-3
Intracelllar PhosphoLipase A family.
   
  
 0.700
acl-9
PlsC domain-containing protein.
   
  
 0.700
F54D7.2
EthanolaminePhosphoTransferase 1 homolog.
   
  
 0.681
wrm-1
Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...]
   
  
 0.671
sec-31
WD_REPEATS_REGION domain-containing protein.
   
 
 0.610
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.