node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F25B5.6 | bcat-1 | F25B5.6b.1 | K02A4.1.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.928 |
F25B5.6 | dld-1 | F25B5.6b.1 | LLC1.3a.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Dihydrolipoyl dehydrogenase, mitochondrial. | 0.796 |
F25B5.6 | mct-3 | F25B5.6b.1 | M03B6.2.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | MFS domain-containing protein. | 0.700 |
F25B5.6 | mel-32 | F25B5.6b.1 | C05D11.11b.2 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. | 0.977 |
F25B5.6 | snf-5 | F25B5.6b.1 | Y46G5A.30.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Sodium-dependent transporter snf-5; Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid (Probable). May additionally have a role in potassium-dependent amino acid absorption. In response to the availability of amino acid nutrients, may play a role in dauer formation. May play a role in promoting fertility. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.534 |
F25B5.6 | thk-1 | F25B5.6b.1 | Y43C5A.5a.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidine kinase. | 0.871 |
F25B5.6 | tyms-1 | F25B5.6b.1 | Y110A7A.4.1 | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidylat_synt domain-containing protein. | 0.961 |
bcat-1 | F25B5.6 | K02A4.1.1 | F25B5.6b.1 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.928 |
bcat-1 | dld-1 | K02A4.1.1 | LLC1.3a.1 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Dihydrolipoyl dehydrogenase, mitochondrial. | 0.670 |
bcat-1 | mct-3 | K02A4.1.1 | M03B6.2.1 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | MFS domain-containing protein. | 0.469 |
bcat-1 | mel-32 | K02A4.1.1 | C05D11.11b.2 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. | 0.673 |
bcat-1 | thk-1 | K02A4.1.1 | Y43C5A.5a.1 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Thymidine kinase. | 0.686 |
bcat-1 | tyms-1 | K02A4.1.1 | Y110A7A.4.1 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Thymidylat_synt domain-containing protein. | 0.556 |
dld-1 | F25B5.6 | LLC1.3a.1 | F25B5.6b.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.796 |
dld-1 | bcat-1 | LLC1.3a.1 | K02A4.1.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.670 |
dld-1 | mct-3 | LLC1.3a.1 | M03B6.2.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | MFS domain-containing protein. | 0.633 |
dld-1 | mel-32 | LLC1.3a.1 | C05D11.11b.2 | Dihydrolipoyl dehydrogenase, mitochondrial. | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. | 0.988 |
dld-1 | thk-1 | LLC1.3a.1 | Y43C5A.5a.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | Thymidine kinase. | 0.723 |
dld-1 | tyms-1 | LLC1.3a.1 | Y110A7A.4.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | Thymidylat_synt domain-containing protein. | 0.743 |
mct-3 | F25B5.6 | M03B6.2.1 | F25B5.6b.1 | MFS domain-containing protein. | Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.700 |