STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cogc-8Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. (743 aa)    
Predicted Functional Partners:
cogc-6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 0.995
cogc-1
Conserved Oligomeric Golgi (COG) Component.
   
 0.995
cogc-5
Conserved Oligomeric Golgi (COG) Component.
   
 0.993
cogc-3
Conserved Oligomeric Golgi (COG) Component.
    
 0.993
cogc-4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function; Belongs to the COG4 family.
   
 0.984
cogc-2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function.
   
 0.982
Y51H7C.41
Uncharacterized protein.
   
 
 0.921
gsnl-1
Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family.
    
 
 0.912
syx-16
t-SNARE coiled-coil homology domain-containing protein.
   
 0.883
syx-5
Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.
   
 0.854
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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