STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
R04B5.6PKS_ER domain-containing protein. (347 aa)    
Predicted Functional Partners:
R04B5.5
PKS_ER domain-containing protein.
  
 
0.956
hxk-1
Phosphotransferase; Belongs to the hexokinase family.
   
 
 0.924
R08D7.7
Uncharacterized sugar kinase R08D7.7; Belongs to the FGGY kinase family.
  
 
 0.917
dhs-21
L-xylulose reductase; Catalyzes the NADPH-dependent reduction of L-xylulose, D- xylulose, L-(+) erythrulose, D-erythrose, D-threose, L-ribulose, 1,4- dibromo-2,3-butanedione and 2,3-heptanedione. Also active against isatin, 9,10-phenanthrenequinone, menadione, 2,3- hexaenadione and 3,4-hexahenadione. No activity observed when tested using NADH rather than NADPH.
   
 
 0.913
hphd-1
Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
  
 
 0.902
coq-2
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family.
  
 
 0.886
W02H5.8
Uncharacterized protein.
  
 0.862
Y48G10A.1
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
  
 
 0.857
F09E5.3
Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.
  
 
  0.827
atic-1
MGS domain-containing protein.
    
 0.823
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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