STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
R05D7.2SPK domain-containing protein. (314 aa)    
Predicted Functional Partners:
Y41C4A.7
Uncharacterized protein.
   
  
 0.844
F44D12.6
Uncharacterized protein.
   
  
 0.843
ZK430.7
WD_REPEATS_REGION domain-containing protein.
      
 0.804
C40H1.3
Uncharacterized protein C40H1.3.
      
 0.758
C54F6.5
Uncharacterized protein.
      
 0.695
F41C3.1
Uncharacterized protein.
      
 0.695
morc-1
Protein morc-1; Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality.
      
 0.668
kreg-1
Protein kreg-1; Plays a role in the stress response to heavy metals such as copper, probably in a fos-1/kgb-1-dependent manner.
      
 0.535
idha-1
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
      
 0.533
let-607
BZIP domain-containing protein.
      
 0.463
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.