STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srw-7G_PROTEIN_RECEP_F1_2 domain-containing protein. (381 aa)    
Predicted Functional Partners:
zipt-2.1
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
      
 0.917
R08F11.4
Methyltranfer_dom domain-containing protein.
    
 
 0.891
zipt-2.3
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
      
 0.853
zipt-7.1
Zinc transporter zipt-7.1; Zinc transporter which regulates intracellular zinc levels. Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function. Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm. The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization.
      
 0.812
F44E7.5
Uncharacterized protein.
      
 0.808
zip-7
BZIP domain-containing protein.
    
 
 0.714
hizr-1
High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated.
    
 
 0.557
zip-8
bZIP transcription factor 8.
    
 
 0.411
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.