STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-269Nuclear Hormone Receptor family. (334 aa)    
Predicted Functional Partners:
moe-3
CCCH-type zinc finger protein moe-3; Zinc-finger protein that may play a role in oocyte maturation and fertility.
      
 0.850
sbds-1
Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with K10C3.5b/EFL1, triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
      
 0.691
egl-38
Paired domain-containing protein.
  
   
 0.588
nhr-157
Nuclear Hormone Receptor family.
  
    0.572
nhr-72
Nuclear hormone receptor family member nhr-75; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
    0.568
lin-1
ETS domain-containing protein.
  
 
 
 0.567
nhr-169
Nuclear hormone receptor family member nhr-169; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
    0.562
mom-2
Protein mom-2; Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such [...]
  
   
 0.542
nhr-174
Nuclear hormone receptor family member nhr-174; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
    0.541
srt-58
Nuclear receptor domain-containing protein.
  
    0.533
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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