STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)    
Predicted Functional Partners:
rde-4
RNA interference promoting factor.
   
 0.959
dcr-1
Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily.
   
 0.931
alg-2
Protein argonaute; Belongs to the argonaute family.
   
 
0.930
lin-41
Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...]
   
 0.928
alg-1
Protein argonaute; Belongs to the argonaute family.
     
0.927
rrf-3
RNA-dependent RNA polymerase Family.
   
  
 0.914
rrf-1
RNA-dependent RNA polymerase Family.
   
  
 0.901
ego-1
RNA-directed RNA polymerase related EGO-1.
   
  
 0.900
mut-16
MUTator.
   
 
 0.889
henn-1
Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...]
   
  
 0.868
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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