node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C01G8.1 | cbd-1 | C01G8.1a.1 | H02I12.1.1 | Uncharacterized protein. | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | 0.999 |
C01G8.1 | cpg-1 | C01G8.1a.1 | C07G2.1a.1 | Uncharacterized protein. | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.999 |
C01G8.1 | egg-1 | C01G8.1a.1 | B0244.8.1 | Uncharacterized protein. | LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] | 0.999 |
C01G8.1 | egg-5 | C01G8.1a.1 | R12E2.10.1 | Uncharacterized protein. | Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.999 |
C01G8.1 | gln-5 | C01G8.1a.1 | F26D10.10.1 | Uncharacterized protein. | Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. | 0.999 |
C01G8.1 | memi-3 | C01G8.1a.1 | H02I12.5.1 | Uncharacterized protein. | MEiosis-to-MItosis transition associated. | 0.999 |
C01G8.1 | mesp-1 | C01G8.1a.1 | C28C12.2.1 | Uncharacterized protein. | MEiotic SPindle. | 0.999 |
C01G8.1 | oma-1 | C01G8.1a.1 | C09G9.6.1 | Uncharacterized protein. | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] | 0.999 |
C01G8.1 | puf-5 | C01G8.1a.1 | F54C9.8.1 | Uncharacterized protein. | Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. | 0.999 |
C01G8.1 | puf-7 | C01G8.1a.1 | B0273.2.2 | Uncharacterized protein. | Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. | 0.869 |
cbd-1 | C01G8.1 | H02I12.1.1 | C01G8.1a.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Uncharacterized protein. | 0.999 |
cbd-1 | cpg-1 | H02I12.1.1 | C07G2.1a.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.999 |
cbd-1 | egg-1 | H02I12.1.1 | B0244.8.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] | 0.999 |
cbd-1 | egg-5 | H02I12.1.1 | R12E2.10.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.999 |
cbd-1 | gln-5 | H02I12.1.1 | F26D10.10.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. | 0.999 |
cbd-1 | memi-3 | H02I12.1.1 | H02I12.5.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | MEiosis-to-MItosis transition associated. | 0.592 |
cbd-1 | mesp-1 | H02I12.1.1 | C28C12.2.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | MEiotic SPindle. | 0.999 |
cbd-1 | oma-1 | H02I12.1.1 | C09G9.6.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] | 0.999 |
cbd-1 | puf-5 | H02I12.1.1 | F54C9.8.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. | 0.999 |
cbd-1 | puf-7 | H02I12.1.1 | B0273.2.2 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. | 0.999 |