STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
inx-16Innexin-16; Structural component of the gap junctions (By similarity). Required for signals downstream of defecation clock. Belongs to the pannexin family. (372 aa)    
Predicted Functional Partners:
pbo-4
Na(+)/H(+) exchanger protein 7; Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells.
   
  
 0.724
nkat-1
Aminotran_1_2 domain-containing protein.
   
  
 0.671
gtl-1
LSDAT_euk domain-containing protein.
   
  
 0.568
inx-15
Innexin; Structural component of the gap junctions. Belongs to the pannexin family.
  
  
0.566
kynu-1
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.
   
  
 0.547
pbo-5
Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
   
  
 0.491
inx-14
Innexin-14; Structural component of the gap junctions.
  
   
0.458
kqt-2
Ion_trans domain-containing protein; Belongs to the potassium channel family.
   
  
 0.458
T28B4.1
F-box domain-containing protein.
  
    0.454
inx-22
Innexin; Structural component of the gap junctions. Belongs to the pannexin family.
  
   
0.437
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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