STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kcc-1K+/Cl-Cotransporter. (1156 aa)    
Predicted Functional Partners:
best-15
Bestrophin homolog 15; Forms chloride channels.
      
 0.694
wnk-1
Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals.
   
 
 0.598
gck-3
Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...]
   
 
 0.551
nkcc-1
Na-K-Cl Cotransporter homolog.
  
 
0.540
kcc-2
K+/Cl-Cotransporter.
  
 
0.521
gars-1
Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family.
   
  
 0.516
kcc-3
Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC.
  
 
0.467
abts-1
Anion exchange protein.
   
 
 0.413
unc-25
Glutamic acid decarboxylase.
  
  
 0.410
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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