node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0334.5 | amx-1 | B0334.5.1 | R13G10.2.1 | Uncharacterized protein. | Amine oxidase family member 1. | 0.745 |
B0334.5 | amx-2 | B0334.5.1 | B0019.1.1 | Uncharacterized protein. | Amino_oxidase domain-containing protein. | 0.743 |
B0334.5 | gcy-15 | B0334.5.1 | ZC239.7.1 | Uncharacterized protein. | Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). | 0.420 |
B0334.5 | lsd-1 | B0334.5.1 | T08D10.2.1 | Uncharacterized protein. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. | 0.746 |
B0334.5 | spr-5 | B0334.5.1 | Y40B1B.6.1 | Uncharacterized protein. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.751 |
C41D11.9 | amx-1 | C41D11.9.1 | R13G10.2.1 | TM2 domain-containing protein C41D11.9. | Amine oxidase family member 1. | 0.705 |
amx-1 | B0334.5 | R13G10.2.1 | B0334.5.1 | Amine oxidase family member 1. | Uncharacterized protein. | 0.745 |
amx-1 | C41D11.9 | R13G10.2.1 | C41D11.9.1 | Amine oxidase family member 1. | TM2 domain-containing protein C41D11.9. | 0.705 |
amx-1 | amx-2 | R13G10.2.1 | B0019.1.1 | Amine oxidase family member 1. | Amino_oxidase domain-containing protein. | 0.696 |
amx-1 | gcy-15 | R13G10.2.1 | ZC239.7.1 | Amine oxidase family member 1. | Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). | 0.671 |
amx-1 | his-40 | R13G10.2.1 | K03A1.1.1 | Amine oxidase family member 1. | Histone H3. | 0.811 |
amx-1 | lsd-1 | R13G10.2.1 | T08D10.2.1 | Amine oxidase family member 1. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. | 0.615 |
amx-1 | rbr-2 | R13G10.2.1 | ZK593.4a.1 | Amine oxidase family member 1. | Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation. | 0.634 |
amx-1 | set-2 | R13G10.2.1 | C26E6.9c.1 | Amine oxidase family member 1. | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] | 0.639 |
amx-1 | spr-1 | R13G10.2.1 | D1014.8.1 | Amine oxidase family member 1. | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | 0.743 |
amx-1 | spr-5 | R13G10.2.1 | Y40B1B.6.1 | Amine oxidase family member 1. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.585 |
amx-2 | B0334.5 | B0019.1.1 | B0334.5.1 | Amino_oxidase domain-containing protein. | Uncharacterized protein. | 0.743 |
amx-2 | amx-1 | B0019.1.1 | R13G10.2.1 | Amino_oxidase domain-containing protein. | Amine oxidase family member 1. | 0.696 |
amx-2 | gcy-15 | B0019.1.1 | ZC239.7.1 | Amino_oxidase domain-containing protein. | Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). | 0.671 |
amx-2 | spr-1 | B0019.1.1 | D1014.8.1 | Amino_oxidase domain-containing protein. | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | 0.520 |