STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pro-1Pre-rRNA-processing protein pro-1; Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation. Required in the soma to promote normal proliferation and prevent germline tumor formation. Belongs to the WD repeat IPI3/WDR18 family. (529 aa)    
Predicted Functional Partners:
Y48A6C.4
Ipi1_N domain-containing protein.
   
 0.999
pro-3
Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm (Probable). Required for normal somatic gonad development and for regulation of germline development and proliferation.
   
 
 0.992
W08E12.7
Peptidase_M24 domain-containing protein.
  
 
 0.991
W07E6.2
WD_REPEATS_REGION domain-containing protein.
   
 
 0.990
ngp-1
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
   
 
 0.989
nol-9
Polynucleotide 5'-hydroxyl-kinase nol-9; Polynucleotide 5'-kinase involved in rRNA processing.
   
 0.985
nst-1
Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues.
   
 0.983
Y48B6A.1
Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.
   
 0.977
nifk-1
RRM domain-containing protein.
   
 
 0.969
pro-2
Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation.
   
  
 0.960
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.