STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hlh-34Helix-loop-helix 34; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development (By similarity). (322 aa)    
Predicted Functional Partners:
aha-1
Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.
   
 
 0.966
cky-1
BHLH-PAS factor.
   
  
 0.816
xdh-1
Xanthine DeHydrogenase homolog.
      
 0.805
unc-42
Homeobox domain-containing protein.
   
  
 0.693
gcy-21
Receptor-type guanylate cyclase gcy-21; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
      
 0.660
inx-17
Innexin-17; Structural component of the gap junctions.
      
 0.660
fax-1
Nuclear receptor domain-containing protein.
  
  
 0.581
ceh-10
Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons.
   
 
 0.551
srd-10
Serpentine Receptor, class D (Delta).
      
 0.550
hlh-26
Helix-loop-helix protein 26; Binds DNA via the E-box sequence 5'-CACGTG-3'. Binds DNA as a homodimer. Represses lag-2 transcription during embryogenesis via Notch signaling, in an unc-37-dependent manner. Also represses tbx-37 independent of Notch signaling.
      
 0.530
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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