V-type proton ATPase subunit e; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Inos-1-P_synth domain-containing protein.

Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...]

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.

Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1- mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...]

Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...]

Nucleolar protein dao-5; Nucleolar protein which binds to RNA polymerase I and rDNA and is required for efficient RNA polymerase I-mediated rDNA transcription. Maintains the epigenetically active status of rDNA chromatin which facilitates rDNA transcription and sustains germline development, ensuring fertility. Plays a role in the modulation of nucleolus size. May play a role in the regulation of lifespan. Belongs to the NOLC1 family.

RNA Binding Motif protein homolog.