node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adt-2 | dbl-1 | F08C6.1a.2 | T25F10.2.1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | TGF_BETA_2 domain-containing protein. | 0.683 |
adt-2 | lon-2 | F08C6.1a.2 | C39E6.1.1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | LONg; Belongs to the glypican family. | 0.463 |
adt-2 | mab-31 | F08C6.1a.2 | Y54E10A.16.1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | Uncharacterized protein. | 0.717 |
adt-2 | sma-10 | F08C6.1a.2 | T21D12.9a.2 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. | 0.664 |
adt-2 | sma-6 | F08C6.1a.2 | C32D5.2.1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.486 |
adt-2 | sma-9 | F08C6.1a.2 | T05A10.1m.1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | SMAll. | 0.768 |
daf-4 | dbl-1 | C05D2.1a.2 | T25F10.2.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | TGF_BETA_2 domain-containing protein. | 0.999 |
daf-4 | drag-1 | C05D2.1a.2 | Y71G12B.16.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family. | 0.648 |
daf-4 | lon-1 | C05D2.1a.2 | F48E8.1a.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | 0.807 |
daf-4 | mab-31 | C05D2.1a.2 | Y54E10A.16.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Uncharacterized protein. | 0.483 |
daf-4 | sma-10 | C05D2.1a.2 | T21D12.9a.2 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. | 0.952 |
daf-4 | sma-6 | C05D2.1a.2 | C32D5.2.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.996 |
daf-4 | sma-9 | C05D2.1a.2 | T05A10.1m.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | SMAll. | 0.889 |
daf-4 | tsp-14 | C05D2.1a.2 | F39C12.3b.1 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Tetraspanin-14; Together with tsp-12, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling. Together with tsp-12, probably acts by modulating the activation of glp-1, Notch-like receptor, to regulate germline maturation ; Belongs to the tetraspanin (TM4SF) family. | 0.677 |
dbl-1 | adt-2 | T25F10.2.1 | F08C6.1a.2 | TGF_BETA_2 domain-containing protein. | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. | 0.683 |
dbl-1 | daf-4 | T25F10.2.1 | C05D2.1a.2 | TGF_BETA_2 domain-containing protein. | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.999 |
dbl-1 | drag-1 | T25F10.2.1 | Y71G12B.16.1 | TGF_BETA_2 domain-containing protein. | RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family. | 0.898 |
dbl-1 | lon-1 | T25F10.2.1 | F48E8.1a.1 | TGF_BETA_2 domain-containing protein. | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. | 0.813 |
dbl-1 | lon-2 | T25F10.2.1 | C39E6.1.1 | TGF_BETA_2 domain-containing protein. | LONg; Belongs to the glypican family. | 0.810 |
dbl-1 | mab-31 | T25F10.2.1 | Y54E10A.16.1 | TGF_BETA_2 domain-containing protein. | Uncharacterized protein. | 0.573 |