node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T13H5.6 | col-109 | T13H5.6.1 | Y38C1BA.3.1 | Uncharacterized protein. | Col_cuticle_N domain-containing protein. | 0.740 |
T13H5.6 | gem-1 | T13H5.6.1 | C49F8.2.1 | Uncharacterized protein. | Gon-2 Extragenic Modifier. | 0.694 |
T13H5.6 | imp-2 | T13H5.6.1 | T05E11.5.1 | Uncharacterized protein. | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. | 0.806 |
Y38F2AR.9 | ile-1 | Y38F2AR.9.1 | K07A1.8.2 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | L-type lectin-like domain-containing protein. | 0.551 |
Y38F2AR.9 | imp-2 | Y38F2AR.9.1 | T05E11.5.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. | 0.625 |
Y38F2AR.9 | sec-61 | Y38F2AR.9.1 | Y57G11C.15a.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Plug_translocon domain-containing protein. | 0.999 |
Y38F2AR.9 | trap-2 | Y38F2AR.9.1 | T04G9.5.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. | 0.969 |
Y38F2AR.9 | trap-3 | Y38F2AR.9.1 | Y38F2AR.2.1 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | TRanslocon-Associated Protein. | 0.976 |
col-109 | T13H5.6 | Y38C1BA.3.1 | T13H5.6.1 | Col_cuticle_N domain-containing protein. | Uncharacterized protein. | 0.740 |
col-109 | gem-1 | Y38C1BA.3.1 | C49F8.2.1 | Col_cuticle_N domain-containing protein. | Gon-2 Extragenic Modifier. | 0.549 |
col-109 | imp-2 | Y38C1BA.3.1 | T05E11.5.1 | Col_cuticle_N domain-containing protein. | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. | 0.698 |
cup-2 | enpl-1 | F25D7.1.1 | T05E11.3a.1 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. | 0.551 |
cup-2 | imp-2 | F25D7.1.1 | T05E11.5.1 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. | 0.733 |
cup-2 | sec-61 | F25D7.1.1 | Y57G11C.15a.1 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. | Plug_translocon domain-containing protein. | 0.874 |
enpl-1 | cup-2 | T05E11.3a.1 | F25D7.1.1 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. | 0.551 |
enpl-1 | ile-1 | T05E11.3a.1 | K07A1.8.2 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. | L-type lectin-like domain-containing protein. | 0.520 |
enpl-1 | imp-2 | T05E11.3a.1 | T05E11.5.1 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. | 0.721 |
enpl-1 | sec-61 | T05E11.3a.1 | Y57G11C.15a.1 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. | Plug_translocon domain-containing protein. | 0.464 |
gem-1 | T13H5.6 | C49F8.2.1 | T13H5.6.1 | Gon-2 Extragenic Modifier. | Uncharacterized protein. | 0.694 |
gem-1 | col-109 | C49F8.2.1 | Y38C1BA.3.1 | Gon-2 Extragenic Modifier. | Col_cuticle_N domain-containing protein. | 0.549 |