node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F57B10.4 | him-3 | F57B10.4.1 | ZK381.1a.2 | Uncharacterized protein. | HORMA domain-containing protein. | 0.752 |
F57B10.4 | htp-1 | F57B10.4.1 | F41H10.10.1 | Uncharacterized protein. | HORMA domain-containing protein. | 0.625 |
F57B10.4 | htp-3 | F57B10.4.1 | F57C9.5.1 | Uncharacterized protein. | HORMA domain-containing protein. | 0.817 |
F57B10.4 | syp-2 | F57B10.4.1 | C24G6.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.801 |
F57B10.4 | zim-3 | F57B10.4.1 | T07G12.11a.1 | Uncharacterized protein. | Zinc finger In Meiosis. | 0.737 |
chk-2 | him-3 | Y60A3A.12.1 | ZK381.1a.2 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | HORMA domain-containing protein. | 0.713 |
chk-2 | htp-1 | Y60A3A.12.1 | F41H10.10.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | HORMA domain-containing protein. | 0.759 |
chk-2 | htp-3 | Y60A3A.12.1 | F57C9.5.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | HORMA domain-containing protein. | 0.717 |
chk-2 | plk-2 | Y60A3A.12.1 | Y71F9B.7.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] | 0.751 |
chk-2 | rad-51 | Y60A3A.12.1 | Y43C5A.6a.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. | 0.909 |
chk-2 | sun-1 | Y60A3A.12.1 | F57B1.2.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. | 0.898 |
chk-2 | syp-2 | Y60A3A.12.1 | C24G6.1.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Uncharacterized protein. | 0.704 |
chk-2 | zim-3 | Y60A3A.12.1 | T07G12.11a.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Zinc finger In Meiosis. | 0.864 |
chk-2 | zyg-12 | Y60A3A.12.1 | ZK546.1b.1 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. | 0.842 |
him-3 | F57B10.4 | ZK381.1a.2 | F57B10.4.1 | HORMA domain-containing protein. | Uncharacterized protein. | 0.752 |
him-3 | chk-2 | ZK381.1a.2 | Y60A3A.12.1 | HORMA domain-containing protein. | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. | 0.713 |
him-3 | htp-1 | ZK381.1a.2 | F41H10.10.1 | HORMA domain-containing protein. | HORMA domain-containing protein. | 0.997 |
him-3 | htp-3 | ZK381.1a.2 | F57C9.5.1 | HORMA domain-containing protein. | HORMA domain-containing protein. | 0.995 |
him-3 | plk-2 | ZK381.1a.2 | Y71F9B.7.1 | HORMA domain-containing protein. | Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] | 0.740 |
him-3 | rad-51 | ZK381.1a.2 | Y43C5A.6a.1 | HORMA domain-containing protein. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. | 0.923 |