STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lin-5Spindle apparatus protein lin-5; Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division. (821 aa)    
Predicted Functional Partners:
gpr-1
G-protein regulator 1; In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement.
   
 
 0.997
aspm-1
Calponin-homology (CH) domain-containing protein.
   
 
 0.995
gpa-16
Guanine nucleotide-binding protein alpha-16 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Belongs to the G-alpha family.
    
 
 0.995
goa-1
Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...]
   
 
 0.993
alh-13
Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
      
 0.956
let-99
Protein let-99; Required for the proper orientation of spindles after the establishment of polarity. May play a role in interactions between the astral microtubules and the cortical cytoskeleton. Required for asymmetric forces on nuclei and spindles. Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation. Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions. Acts antagonistically to the gpr-1/2 signaling pathway. Regu [...]
   
  
 0.921
gpr-2
G-protein regulator 2; In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement.
   
 
 0.873
pkc-3
Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.
   
 
 0.862
dyrb-1
Dynein light chain roadblock; Belongs to the GAMAD family.
    
 
 0.856
cal-1
Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function.
      
 0.784
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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