STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pigv-1GPI mannosyltransferase pigv-1; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis (By similarity). Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). Required for maintenance of epithelial integrity during embryogenesis. Belongs to the PIGV family. (672 aa)    
Predicted Functional Partners:
T27F7.4
Mannosyltransferase.
   
 0.983
B0491.1
GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly.
   
 
 0.977
pign-1
PigN domain-containing protein.
   
 0.967
dpm-3
Probable dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
     
 0.958
hpo-4
Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family.
    
 
 0.949
piga-1
PIGA domain-containing protein.
   
  
 0.933
hpo-3
GlycosylPhosphatidylinositol Anchor Attachment 1 homolog.
   
 
 0.905
Y48E1B.2
G domain-containing protein.
  
 
 0.905
C27A12.9
PhosphatidylInositol Glycan anchor biosynthesis class O.
   
 
 0.898
F38E1.9
Mannose-P-dolichol utilization defect 1 protein homolog.
   
  
 0.896
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.