STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-217Nuclear hormone receptor family member nhr-217; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (383 aa)    
Predicted Functional Partners:
nhr-276
Nuclear Hormone Receptor family.
   
  
 0.893
Y87G2A.2
Uncharacterized protein.
      
 0.891
T27F6.6
Putative neutral sphingomyelinase.
      
 0.810
ces-2
Cell death specification protein 2; Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'; Belongs to the bZIP family.
    
 
 0.709
scrm-2
Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family.
    
 
 0.708
ech-7
Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
      
 0.699
lagr-1
Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides.
      
 0.660
F25E2.3
Uncharacterized protein.
      
 0.581
acox-1.4
Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.
      
 0.550
acox-1.3
Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.
      
 0.539
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.