STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcbd-1Putative pterin-4-alpha-carbinolamine dehydratase. (142 aa)    
Predicted Functional Partners:
qdpr-1
Quinoid DihydroPteridine Reductase.
   
 
 0.994
pah-1
Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  
 0.993
cat-2
Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior.
  
 0.984
tph-1
BH4_AAA_HYDROXYL_2 domain-containing protein.
  
 0.984
agmo-1
Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids; Belongs to the sterol desaturase family. TMEM195 subfamily.
      
 0.809
sup-18
Iodotyrosine dehalogenase 1 homolog; May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.
  
 
  0.805
ptps-1
Putative 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity); Belongs to the PTPS family.
  
  
 0.744
hgo-1
Homogentisate 1,2-dioxygenase.
  
  
 0.744
dhfr-1
Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
   
  
 0.741
aqp-2
AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.692
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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